| 摘要 |
<p>The present invention is to provide a method for producing an optically active erythro-3-amino-2-hydroxybutyric ester as an important intermediate of pharmaceutical agents, specifically HIV protease inhibitor, at a high purity and at a high yield. More specifically, the present invention relates to a method for producing an optically active erythro-3-amino-2-hydroxybutyric ester, compwashing oxidizing the hydroxyl group at the 2-position of an optically active 3-amino-2-hydroxybutyric ester, optically active at 3-position, as represented by the formula (I); <CHEM> (wherein R<1> represents phenyl group or cyclohexyl group; R<2> represents a protective group and R<3> represents alcohol residue; the steric configuration of *1 represents S configuration or R configuration), and then reducing erythro-selectively the resulting product by using aluminium alkoxide.</p> |
