Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. This invention relates to the identification of a new murine caspase and its human homologue. The new molecules are most related to human/murine caspase-2 and human caspase-9 and possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a very short prodomain. Northern blot analysis revealed that mRNA expression of the new caspase is predominant in skin.
申请公布号
WO0004169(A1)
申请公布日期
2000.01.27
申请号
WO1999EP04939
申请日期
1999.07.12
申请人
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW;VAN DE CRAEN, MARC;DECLERCQ, WIM;VANDENABEELE, PETER;FIERS, WALTER
发明人
VAN DE CRAEN, MARC;DECLERCQ, WIM;VANDENABEELE, PETER;FIERS, WALTER