| 摘要 |
The present invention relates to a nucleic acid construct characterized in that it contains the following constituents: constituent a): at least one promoter, b): DNA coding for at least one recombinant transactivator, whereb y the transcription thereof is a) activated and contains constituent b1): DNA coding for a DNA binding domain, constituent b2): DNA coding for a transactivation domain that is rich in glutamine, serine and threonine, constituent c): at least one DNA sequence for binding an expression product of constituent b), constituent d): at least one minimal promoter containing the CDE-CHR element or the E2F-BS-CHR element and bound with its 5'-end to the 3 '- end of constituent c), constituent e): at least one effector gene, whereby t he transcription thereof is activated by binding the expression product of constituent b) to constituent c). The invention also relates to the producti on and use of said nucleic acid construct, vectors containing the nucleic acid construct, cells containing said vectors and to the use of the nucleic acid construct in the production of a medicament.
|
