发明名称 |
NEW CASPASE HOMOLOGUE |
摘要 |
Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. This invention relates to the identification of a new murine caspase and its human homologue. The new molecules are most relat ed to human/murine caspase-2 and human caspase-9 and possesses all the typical amino acid residues of the caspases involved in catalysis, including the QAC RG box, and contains no or only a very short prodomain. Northern blot analysis revealed that mRNA expression of the new caspase is predominant in skin.</SD OAB>
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申请公布号 |
CA2335099(A1) |
申请公布日期 |
2000.01.27 |
申请号 |
CA19992335099 |
申请日期 |
1999.07.12 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
VANDENABEELE, PETER;FIERS, WALTER;DECLERCQ, WIM;VAN DE CRAEN, MARC |
分类号 |
A61K38/00;A61K38/48;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/57;C12Q1/37;(IPC1-7):C12N15/57 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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