| 摘要 |
PURPOSE: A N-aminoalkyl-1-biphenylenyl-2-carboxamide being combined to a brain dopamine receptor subtype and a pharmaceutical composition including the compound are provided. CONSTITUTION: Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof wherein: R1, R2, R3, R4, R5, R6 and R7 independently represent hydrogen, halogen, hydroxy, alkyl, alkoxy, amino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, cyano, nitro, trifluoromethyl, or trifluoromethoxy; R8 is hydrogen or lower alkyl; X represents an optionally substituted alkylene group; and Y represents a mono- di- or tri-substituted cyclic amino group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which responds to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extra pyramidal side effects associated with the use of conventional neuroleptic agents.
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