摘要 |
The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).
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申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
BAECK, ANDRE;GHOSH, CHANCHAL KUMAR;GRAYCAR, THOMAS PAUL;BOTT, RICHARD RAY;WILSON, LORI JEAN;BRODE, PHILIP FREDERICK;BARNETT, BOBBY LEE;RUBINGH, DONN NELTON |