发明名称 Process for producing stabilized pharmaceutical composition
摘要 The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonyl methyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
申请公布号 US6017560(A) 申请公布日期 2000.01.25
申请号 US19980196664 申请日期 1998.11.19
申请人 TAKEDA CHEMICAL INDUSTRIES, LTD. 发明人 MAKINO, TADASHI;TABATA, TETSURO;HIRAI, SHIN-ICHIRO
分类号 A61K9/16;A61K9/20;A61K9/30;A61K9/50;A61K31/44;A61K31/4439;A61K47/02;C07D401/12;(IPC1-7):A61K9/30 主分类号 A61K9/16
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