| 摘要 |
Nucleotide analogs and intermediates (3), (4), (5), (6), (7), (8) and (9) are new. Nucleotide analogs and intermediates (3), (4), (5), (6), (7), (8) and (9) are new. G = 1-24C alkoxy, 2-24C alkenyloxy, aryloxy, arylmethoxy, cycloalkyloxy, cyclalkenyloxy, (optionally substituted and containing at least one hetero atoms and at least one halo) or an alpha -amino acid residue, with the terminal N atom free or protected by Fmoc, Boc or trialkylsilyl; A', B', and D' = H, 1-24C alkyl, 2-24C alkenyl, alkynyl, aryl, arylmethyl, cycloalkyl, or cycloalkenyl (optionally substituted and containing at least one hetero atoms and at least one halo); K' = a natural puric, pyrimidic, adenine, hypoxanthine, guanine, thymine, or cytidine nucleic base (optionally protected and optionally modified, especially by F or CF3, halogens, cyclopropylamine, cyclobutylamine, cyclopentylamine, cyclohexylamine, oxo or amine) or it is a puric pseudo-base with the six-membered ring open and carrying various functional groups, the coupling being effected through the C1 position of the sugar and the N1 position for pyrimidic groups or the N7 position for puric bases; L', M', N', and Q' = H, halo, 1-24C alkyl, 2-24C alkenyl, 2-24C alkynyl, aryl, arylmethyl as previously defined, azido, isonitrile, methylisonitrile, NR7R8, SR7; R7 = H, 1-24C alkyl, 2-24C alkenyl, 2-24C alkynyl, 1-24C alkyloxy, 2-24C alkenyloxy, aryl, arylmethyl, aryloxy, or arylmethyloxy as previously defined, a group comprising at least one rings of 3, 5, or 6 bonds containing at least one heteroatoms in the structure, at least one halogens, at least one double bonds and optionally substituted; R8 = H, free or substituted nitrogen, or R7; X = O, S, NR7, CH2, CHal2, C(R8)2, CR8Hal, CHOH, OR7 or CR8 when forming a double bond between positions 4 and 5; and Y' = O or S. |
