| 摘要 |
New cyclic compounds and their salts are new. Cyclic compounds are of formula (I): X, Y = CH2, O, S o NRa; R = H, 1-7C alkyl, phthalamido-(1-7C) alkyl, 3-12C cycloalkyl, (CH2)pCOORb or 6-10C aryl or 3-10-membered heterocycle comprising 1-4 endocyclic heteroatoms of O, S and N (both optionally substituted by one or more of Z or 1-7C alkylene), 6-10C aryl-(1-7C) alkyl; R1 = H, 1-7C alkyl, 1-7C hydroxyalkyl, 6-10C aryl (optionally substituted by one or more of W), P(O)(OR8)(OR9), (CH2)tCOORc or CONR10R11; R2, R3 = H, 1-7C alkyl, 3-12C cycloalkyl, 6-10C aryl, 6-10C aryl-(1-7C) alkyl, 3-10-membered heterocycle comprising 1-4 endocyclic heteroatoms of O, S and N or fluorenyl (aryl, heterocycle and fluorenyl optionally substituted by one or more of Z or 1-7C alkylene) or, together, R2 and R3 form (CH2)r1 or group of formula (a); and R4-R7 = H, 1-7C alkyl or 6-10C aryl or 3-10-membered heterocycle comprising 1-4 endocyclic heteroatoms of O, S and N (optionally substituted by one or more of Z), provided that: (i) when R2, R3, R5 and R7 = H, X, Y = O, R4 = CH3 and R6 = H or CH3, then R1 and R, together with the C to which they are attached, do not form C(CH3)(COOCH3), C(CH3)(CH2OH), C(C6H5)(COOCH3) or C(C6H5)(CH2OH); and (ii) when R4-R7 = H, X, Y = O and R = pyridyl or optionally substituted piperidyl, then R1 is not optionally substituted phenyl. An Independent claim is also included for intermediate diols chosen from 2,2-bis-(4-fluorophenyl)propane-1,3-diol, 2,2-bis(3-trifluoromethylphenyl)propane-1,3-diol, 5-hydroxymethyl-5H-dibenzo(a,d)cyclohepten-5-ylmethanol and (9-hydroxymethyl-9H-xanthen-9-yl)methanol. |
