| 摘要 |
Preparation of phosphonoformic acid analogues containing one, two, three, or more sulfur atoms are described, with specific examples. Such compounds, not excluding cognates, derivatives, and homologues thereof, are proposed to be used directly, or as prodrugs, in treating viral infections, including but n ot limited to HIV, herpesviruses including HSV, EBV, VZV, CMV, HSV-6 and HSV-8 (Kaposi's sarcoma); HPV; rhinoviruses; and hepatitis-linked viruses. They ar e also proposed to be used in treating neoplasms, and for diagnosis and therap y of diseases of bone metabolism. The compounds of the present invention are also designed as to create novel biologically active compounds or prodrugs.< /SDOAB>
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