| 摘要 |
The present invention relates to modulation and/or regulation of proteasomal activity. The invention provides assay methods for identifying compounds which inhibit viral replication and pathogenesis, for identifying inhibitors of the nuclease-inhibitory function of the human immunodeficiency virus TAT protein, for identifying inhibitors of the protease-inhibitory function of the human immunodeficiency virus TAT protein, for identifying compounds which change the concentrations of regulatory proteins by modulating the rate of proteasomal destruction of specific mRNAs, and methods for generating resistance to bacterial or viral infection damage. The invention provides assays, kits for carrying out said assays, compounds identified by said assays, together with amino acid sequences encoding said compounds and medicinal compositions derived therefrom. Where legally permissible the invention also provides methods of treatment based on the modulation/regulation of proteasomal activity. |
