PHARMACEUTICAL PREPARATION FOR TREATMENT OF PRE-ECLAMPTIC STATE AND PREMATURE LABOUR, COMPRESING A COMBINATION OF A PROGESTATIONAL DRUG TOGETHER WITH A SUBSTRATE OF SYNTHESIS OF NITROGEN OXIDE AND/OR A DONOR OF NITROGEN OXIDE, AND APPLICATION OF THIS COMPOSITION

摘要

Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.