| 摘要 |
FIELD: organic synthesis and biologically-active compounds. SUBSTANCE: invention provides new pyrido[3,2-e] pyrazinones of general formula I: <EMI ID=0.498 HE=30 WI=33 TI=CHI> (I), wherein X, Y, and Z are nitrogen or group CR , provided that at least one of X, Y, Z is nitrogen; R is optionally aryl- substituted C<SB>1</SB>-C<SB>10</SB>-alkyl; R hydrogen, C<SB>5</SB>-C<SB>7</SB>-cycloalkyl, or C<SB>1</SB>-C<SB>10</SB>-alkyl optionally substituted by radical selected from group including aryl, aryloxy, hydroxyl, sulfonyl, pyridyl, and quinolyl; A is methylene, group NR , or oxygen atom; R hydrogen or C<SB>1</SB>-C<SB>6</SB>-alkyl; or their physiologically tolerable salts exhibiting anti-asthmatic and antiallergenic effects. EFFECT: increased choice of pharmaceutically active compounds. 8 cl, 2 tbl, 53 ex |
