| 摘要 |
Described herein are compounds with affinity for the 5-HT6 receptor, which have general formula (I), wherein R<1>, R<2>, R<3> and R<4> are independently selected from the group consisting of H, halo, OH, C1-6alkyl, C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl and others; R<5> is selected from the group consisting of SO2Ar, C(O)Ar, Ar and CH2Ar; R<6> and R<7> are independently selected from the group consisting of H, C1-6alkyl, optionally substituted phenyl and optionally substituted benzyl; ----- represents a single or double bond; n is selected from an integer of from 1-3; X is selected from the group consisting of CR<17> and N; Z is selected from the group consisting of C, CH and N, provided that when ----- is a double bond, Z is C and when ----- is a single bond, Z is selected from CH and N; Ar is an optionally substituted aromatic group selected from the group consisting of phenyl, pyridyl, thienyl, furanyl, naphthyl, quinolyl and isoquinolyl; R<16> is selected from the group consisting of H, C1-6alkyl and benzyl. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
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