CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS

摘要

This invention relates to compounds which have activity as 5-HT1A agonists a nd antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer. Useful compounds are those of formu la (I) where: X is selected from the group consisting of (1), (2), (3); n is selected from the integers 1 through 5; R1 is optionally substituted C6-C10- aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R2 is selected from the group consisting of H and C1-C6 alkyl; R3 is selected from the group consisting of H, COR5, COOR5, and CONR5R6; R4, R5 and R6 are as defined hereinabove; or an optical isomer; or a pharmaceutical ly acceptable salt thereof.