发明名称 |
Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
摘要 |
<p>This invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The improvement resides in a select group of non-steroid ligands which show improved activity over known ligands.</p> |
申请公布号 |
EP0965644(A2) |
申请公布日期 |
1999.12.22 |
申请号 |
EP19990304444 |
申请日期 |
1999.06.08 |
申请人 |
RHEOGENE HOLDINGS INC. |
发明人 |
CARLSON, GLENN RICHARD;CRESS, DEAN ERVIN;DHADIALLA, TARLOCHAN SINGH;HORMANN, ROBERT EUGENE;LE, DAT PHAT |
分类号 |
C12N15/63;C12N15/09;C07C243/38;C07D319/18;C12P21/02;C12Q1/68;(IPC1-7):C12N15/82;C12P21/00;C07K14/705;C07K14/72;C07D307/79;C12N15/85;C07D319/20 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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