发明名称 |
Methods and compositions for diagnosing tauopathies |
摘要 |
The present invention relates generally to methods and compositions for the diagnosis, modeling and treatment of tau-related pathologies. In particular, the present invention shows that mutations in the tau gene lead to neurofibrillary tangle formation. More specifically gene mutations are described that lead to alterations in ratios of tau isoforms are shown to lead to the formation of abnormal tau filaments. |
申请公布号 |
AU4322999(A) |
申请公布日期 |
1999.12.20 |
申请号 |
AU19990043229 |
申请日期 |
1999.05.28 |
申请人 |
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE |
发明人 |
BERNARDINO GHETTI;MARIA GRAZIA SPILLANTINI;JILL R. MURRELL;MICHEL GOEDERT;MARTIN R. FARLOW;AARON KLUG |
分类号 |
A61K38/00;A61K38/17;A61K48/00;A61P25/28;C07K14/47;C07K16/18;C12Q1/68;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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