发明名称 |
VACCINATION STRATEGY TO PREVENT AND TREAT CANCERS |
摘要 |
A cellular immune response is induced to a non-immunogenic or weakly immunogenic target protein expressed by tumor cells, by administering to a mammalian subject an amount of a therapeutic antigen effective to induce a cellular immune response to the target protein. The therapeutic antigen is a n immunogenic peptide having an MHC-binding portion which binds to the major histocompatibility complex (MHC) and an immune-recognition portion which is recognized by T-cells. The therapeutic antigen is derived from the non- immunogenic or weakly immunogenic target protein such that the MHC-binding portion binds to MHC with a greater affinity than the target protein without material alteration of the immune-recognition portion. The therapeutic antig en may include a sorting signal which directs the transport of the therapeutic antigen into the endoplasmic reticulum and into the endosome/lysosome to facilitate loading of the peptide onto MHC class I and class II molecules, respectively, to facilitate loading of the protein onto MHC molecules for presentation to the immune system.
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申请公布号 |
CA2331378(A1) |
申请公布日期 |
1999.12.16 |
申请号 |
CA19992331378 |
申请日期 |
1999.06.11 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
HOUGHTON, ALAN N.;NIKOLICH-ZUGICH, JANKO;DYALL, RUBEN |
分类号 |
A61K39/00;A61P35/00;(IPC1-7):A61K38/00;A61K38/04;A61K38/08;A61K38/10 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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