MULTIBINDING AGENTS THAT MODULATE PPAR.GAMMA. AND RXR RECEPTORS

摘要

Disclosed are novel multi-binding compounds (agents) which bind to PPAR.gamma. receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes and/or functions thereof. The ligands are capable of binding to either a PPAR.gamma. receptor or a RXR receptor, so long as at least one ligand of the multi-binding compound binds to a PPAR.gamma. receptor. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the PPAR.gamma. receptor.