发明名称 |
Antisense modulation of novel anti-apoptotic bcl-2-related proteins |
摘要 |
Compositions and methods are provided for modulating the expression of novel anti-apoptotic bcl-2-related proteins. Antisense oligonucleotides targeted to nucleic acids encoding the human novel anti-apoptotic bcl-2-related proteins A1 and mcl-1 are preferred. Methods of using these compounds for modulation of novel anti-apoptotic bcl-2-related protein expression and for treatment of diseases associated with expression of novel anti-apoptotic bcl-2-related proteins are also provided. Also provided are methods of using these compounds for promoting apoptosis and for treatment of diseases for which promotion of apoptosis is desired.
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申请公布号 |
US6001992(A) |
申请公布日期 |
1999.12.14 |
申请号 |
US19990226568 |
申请日期 |
1999.01.07 |
申请人 |
ISIS PHARMACEUTICALS INC. |
发明人 |
ACKERMANN, ELIZABETH J.;BENNETT, C. FRANK;DEAN, NICHOLAS M.;MARCUSSON, ERIC G. |
分类号 |
C12N15/09;A61K31/7105;A61K31/711;A61K31/712;A61K31/7125;A61K33/24;A61K45/00;A61K48/00;A61P35/00;C12N5/10;C12N15/113;(IPC1-7):C07H21/04;C07H21/02;C12N15/63;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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