Enzymatic reduction of ketone groups in 6-cyano-3,5-dihydroxy-hexanoic alkyl ester

摘要

PCT No. PCT/GB96/01422 Sec. 371 Date Dec. 23, 1997 Sec. 102(e) Date Dec. 23, 1997 PCT Filed Jun. 17, 1996 PCT Pub. No. WO97/00968 PCT Pub. Date Jan. 9, 1997A compound of formula (III) is produced by selectively reducing a compound of formula (II) using a reductase possessing the properties of one produced by Beauveria, Candida, Kluyveromyces, Torulaspora or Pichia. or A compound of formula is produced by selectively reducing a compound of formula II using a reductase possessing the properties of one produced by Candida pelliculosa, Neurospora crassa, Pichia trehalophila or preferably Hansenula anomola.