| 摘要 |
PROBLEM TO BE SOLVED: To obtain a sialic acid derivative useful as an antiviral, capable of showing strongly inhibitory actions on sialidase being a membrane protein of influenza virus and on hemagglutinin. SOLUTION: This compound is shown by formula I [R<1> is H or a 1-6C alkyl; R<2> is a (substituted) phenyl, a 1-20C alkyl or the like; R<3> is H or a (substituted) OH; R<4> is H, a halogen or the like; R<5> to R<8> are each a (substituted) OH; Ac is acetyl; with the proviso that R<3> and R<4> are not H at the same time] such as methyl(p-nitrophenyl 5-acetamide-4,7,8,9-tetra-O-acetamide-5-deoxy-α-D-erythro- L-gluco-2-nonulopyranosido)nate. The compound of formula I is obtained, in the case of the exemplified compound, by reacting a glucosyl bromide of formula II (Me is methyl) with sodium p-nitrophenoxide in a solvent such as N,N- dimethylformamide, for example, at a room temperature for 12 hours.
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