发明名称 |
STABILIZATION OF COMPOSITIONS CONTAINING ACE INHIBITORS USING MAGNESIUM OXIDE |
摘要 |
The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms of degradation when prepared in a pharmaceutical composition consisting essentially of magnesium oxide as the stabilizing agent. The presence of magnesium oxide also lends itself to favorable processing conditions during the manufacture of ACE inhibitor-containing compositions, especially processing by wet granulation.
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申请公布号 |
WO9962560(A1) |
申请公布日期 |
1999.12.09 |
申请号 |
WO1999US10189 |
申请日期 |
1999.05.10 |
申请人 |
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发明人 |
DANIEL, JANE, ELLEN;HARRIS, MICHAEL, RAY;HOKANSON, GERARD, CLIFFORD;WEISS, JAY |
分类号 |
A61K9/16;A61K9/20;A61K31/401;A61K31/445;A61K31/47;A61K31/472;A61K31/475;A61K33/08;A61K45/06;A61K47/02;A61K47/26;A61P9/12;A61P43/00;(IPC1-7):A61K47/02 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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