发明名称 |
IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF |
摘要 |
Immunomodulatory oligonucleotide compositions are disclosed. These oligonucleotides comprise an immunostimulatory hexanucleotide sequence comprising a modified cytosine. These oligonucleotides can be administered in conjunction with an immunomodulatory peptide or antigen. Methods of modulating an immune response upon administration of the oligonucleotide comprising a modified immunostimulatory sequence are also disclosed.
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申请公布号 |
CA2330225(A1) |
申请公布日期 |
1999.12.09 |
申请号 |
CA19992330225 |
申请日期 |
1999.06.04 |
申请人 |
DYNAVAX TECHNOLOGIES CORPORATION |
发明人 |
SCHWARTZ, DAVID |
分类号 |
A61K39/39;A61K47/48;A61P37/04;C07H21/00;C12N15/117;(IPC1-7):C07H21/00;A61K38/00;A61K39/00;C07K2/00;C07K14/52;A61K31/70;A61K31/715 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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