| 摘要 |
<p>PROBLEM TO BE SOLVED: To industrially and advantageously produce the subject derivative useful as an intermediate for a therapeutic agent for hyperlipemia by regioselectively reducing a specific derivative. SOLUTION: A 2,4-dihydroxyadipic acid ester derivative represented by formula I (R<1> is an ester, carboxyl or the like; R<2> is an alkyl, an aryl or an aralkyl; R<3> and R<4> are each H, a silyl type protecting group or the like) is regioselectively reduced to produce the objective derivative represented by formula II (e.g. t-butyl 3,5-O-isopropylidene-3,5-dihyciroxy-6-oxohexanoate). In the reduction, a hydride reducing agent, e.g. diisobutylaluminum hydride is preferably used as a reducing agent. Furthermore, the reaction is preferably conducted in, e.g. an inert aprotic solvent at -90 to -50 deg.C.</p> |
