Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists

摘要

The present invention relates to thienyl substituted acylguanidine derivatives, such as compounds of the formula I, in which R<1>, R<2>, R<4>, R<6>, A, B und D have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the present invention are valuable pharmaceutical active compounds. They are vitronectin receptor antagonists and inhibitors of bone resorption by osteoclasts and are suitable, for example, for the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example of osteoporosis. The invention furthermore relates to processes for the preparation of thienyl substituted acylguanidines, their use, in particular as pharmaceutical active ingredients, and pharmaceutical preparations comprising them.