发明名称 |
Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis |
摘要 |
It has been demonstrated that antidiabetic thiazolidine and oxazolidine derivatives (glitazones) exhibit novel effects on apoptosis of cardiomyocytes. These substances are capable of greatly decreasing apoptosis by a pathway that is not Caspase 3 dependent. Addition of IGF1 to the treatment further prevents apoptosis. Glitazones alone or glitazones plus IGF1 should be administered at the beginning of a myocardial infarction and continued through the recuperation period to reduce morbidity and prevent unfavorable remodeling of the myocardium. |
申请公布号 |
AU4005299(A) |
申请公布日期 |
1999.12.06 |
申请号 |
AU19990040052 |
申请日期 |
1999.05.19 |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PING H. WANG |
分类号 |
A61K31/42;A61K31/423;A61K31/426;A61K31/427;A61K31/4439;A61K31/5377;A61K38/30 |
主分类号 |
A61K31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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