| 摘要 |
The present invention relates to use of small organic compounds acting as opioid receptor ligands for the treatment of vasomotor disturbances. In particular the present invention relates to the triazaspiro compounds of general formula (Ia) or (Ib) wherein R<1> is selected among phenyl, arylalkyl or thienyl; R<2> is selected among aminophenyl, C1-6-monoalkylaminophenyl, C1-6-dialkylaminophenyl, cyanophenyl, C2-6-alkylphenyl, naphthyl, tetrahydronaphthyl, furanyl, indanyl, benzothienyl or benzofuranyl; R<3> is hydrogen, C1-6-alkyl, phenyl, benzyl, or acetyl; R<4> is hydrogen or (CH2)m-(CHR<9>)-(CH2)p-AR<11>; R<5> is hydrogen or C1-4-alkyl; z is CHR<10> wherein R<10> is hydrogen, C1-6-alkyl, phenyl or arylalkyl - or z is C2-8-alkylene, C2-8-alkenylene or C2-8-alkynylene; n is 1 or 2; or a pharmaceutically acceptable salt thereof for the treatment of migraine, non insulin dependent diabetes mellitus (type II diabetes), sepsis, inflammation, incontinence and/or vasomotor disturbances, in particular the peripheral vasomotor effects known as hot flushes or hot flashes. |
