| 摘要 |
The invention relates to the targeted delivery of substances to cells. The invention provides a method for selecting at least one mutant protein derived from a viral protein as a ligand capable of binding to a cell-surface receptor, comprising displaying at least one mutant of said protein on the surface of a micro-organism expressing said protein, further comprising selecting at least one such a mutant micro-organism for its capacity to bind to said receptor further comprising incorporating said protein in a virus-like particle or gene-delivery vehicle allowing targeting of said virus-like particle or gene-delivery vehicle to cells carrying said receptor. |
