FUMAGILLIN ANALOGS AND THEIR USE AS ANGIOGENESIS INHIBITORS

摘要

The present invention relates to angiogenesis-inhibiting compounds represented by formula (I) wherein R1 through R5 are as defined herein. Compounds of the invention are analogs of fumagillin and are useful in therapy and prophylaxis of disease states associated with angiogenesis such as cancer, diabetic retinopathy and inflammatory diseases (rheumatism, psoriasis etc.).