CYCLODEXTRIN COMPLEXES

摘要

Compositions which include a complex of a biologically active agent and a cyclodextrin, which is encapsulated in a polymer, and methods of preparation and use thereof are disclosed. The polymers are preferably water-insoluble, biodegradable polymers such as a polyanhydride, polyester, or polylactone. The biologically active agent includes reactive groups which would react with the polymers if it was not complexed with a cyclodextrin. In addition to minimizing or preventing interactions between the agent and the polymer, the cyclodextrin helps provide more linear release of the incorporated agent rather than burst release, acts as a surfactant to help stabilize emulsions during microparticle preparation, and allows for improved re-suspension of lyophilized microparticles relative to particles that do not include a cyclodextrin. In addition, cyclodextrin drug complexes can be loaded to contain higher concentrations of a drug than complexes without cyclodextrin. The devices and particles can be used to deliver therapeutic, prophylactic and/or diagnostic agents to a patient in need thereof.