发明名称 |
Targeted gene delivery through the human cationic amino acid transporter-1 (hCAT1) |
摘要 |
<p>The invention relates to the targeted delivery of substances to cells. The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are for example ligands that can bind to the human transporter of cationic L-amino acids (hCAT1). Such hCAT1 binding molecules find applications in the design of vector systems for entry into human or primate cells. Preferred are retroviral envelope molecules, which - when incorporated in a virus particle - can infect hCAT1 positive cells at high frequencies. Also within the scope of the invention are methods for the design of such hCAT1 binding molecules.</p> |
申请公布号 |
EP0960942(A2) |
申请公布日期 |
1999.12.01 |
申请号 |
EP19990201593 |
申请日期 |
1999.05.20 |
申请人 |
INTROGENE B.V. |
发明人 |
VAN ES, HELMUTH;VERLINDEN, STEFAN;HAVENGA, MENZO |
分类号 |
C07K14/075;C12N15/861;(IPC1-7):C12N15/87;C12N7/04;C12N15/86 |
主分类号 |
C07K14/075 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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