| 摘要 |
The compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: R1 is hydrogen, alkyl, cyclic or bicyclic alkyl, alkanoyl, alkylsulphonyl, aroyl, arylalkenoyl, arylsulphonyl, arylalkanoyl or arylalkylsulphonyl; R2 is hydrogen, alkyl or cyclic or bicyclic alkyl; A is a group of formula (II) or Het where Het is selected from the group of formulae (III) and wherein R7, R8 and R9 are as defined in the specification; R3 and R4 are independently hydrogen, alkyl, or cyclic or bicyclic alkyl, perfluoroalkyl, hydroxyalkyl, alkoxyalkyl or fluoro; or, when taken together, form a spirocyclic ring containing a total of 3-7 carbon atoms; R5 and R6 are independently cyano, nitro, amino, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, mono- or dialkylamino, sulphonamide, alkylsulphonamido, arylsulfonamido, alkylcarboxamido, arylcarboxamido, alkylsulphonyl, perfluoroalkylsulphonyl, arylsulphonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl, carboalkoxy, hydroxyl, or hydrogen are claimed.
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