STRAIN STREPTOMYCES CREMEUS SUBSPECIES NEBRAMYCINI FBM-0002 - PRODUCER OF APRAMYCIN

摘要

FIELD: biotechnology, antibiotics. SUBSTANCE: the strain Streptomyces cremeus subsp. nebramycini FBM-0002 as a producer of monocomponent apramycin is obtained from the population of the strain St. cremeus subsp. nebramycini N 2242 forming nebramycin complex (apromycin and tobramycin) by induced mutagenesis and the following selection of clones showing the resistance to analogs of amino acids. The new strain shows the enhanced synthesis of apramycin at biological activity 5000 mcg/ml. EFFECT: increased synthesis and activity of the strain. 1 tbl, 1 ex