N-CYANO-N'-PYRIDYLGUANIDINES OR THEIR N-OXIDES, OR THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF TUMOR CELLS PROLIFERATION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to N-cyano-N'-pyridyl-guanidines of the formula (I) where R, R', R'' - are hydrogen or halogen atoms, C1-8-alkylene possibly substituted with hydroxyl; X - oxygen atom, -S(O)n-; n = 1 or 2, or NH, its tautomeric forms, or their N-oxides, or their pharmaceutically acceptable nontoxic salts that are antagonists of serotonine (5-HT) and some of their inhibit tumor cells proliferation. EFFECT: improved method of synthesis, valuable pharmacological and antitumor properties. 17 cl, 3 tbl, 22 ex