CONJUGATE OF THERAPEUTIC AGENT FOR JOINT DISEASE AND HYALURONIC ACID

摘要

Remedies for joint diseases bound to hyaluronic acid, its derivatives or sal ts thereof by which the remedies can be pooled in the joint cavity. Namely, one or more remedies for joint diseases bound to hyaluronic acid, its derivative s or salts thereof; a process for producing the above bound products which comprises binding a remedy for joint disease (for example, a matrix protease inhibitor) at a site not affecting the activity of the drug to a carboxyl group, a hydroxyl group or a functional group at the reducing end of hyaluronic acid, its derivative or a salt thereof either by direct chemical reaction or via a spacer; and drugs containing these bound products.