发明名称 |
A LIVING CHIMERIC SKIN REPLACEMENT |
摘要 |
The invention comprises skin replacements for improved wound healing. In one embodiment, the skin replacement is chimeric and comprises harvesting autologous epithelial cells from a patient and seeding them onto a biocompatible substrate containing allogeneic epithelial cells cultured in vitro. The living chimeric skin replacement may be implanted over a permanent dermal replacement previously implanted at the wound site. In another embodiment the skin replacement is a composite comprising an inner, middle and outer component, comprising (a) an inner component comprising a biocompatible dermal construct having a biodegradable or removable scaffold as a base; (b) a middle component comprising epithelial cells; and (c) an outer component comprising epithelial cells cultured in vitro on a dermal construct comprising a dermal portion having a biodegradable or removable scaffold as a base, said dermal portion being combined with a transitional covering and facing inward toward said middle component of epithelial cells. The invention further comprises methods of making and implanting the various skin replacements of the invention. |
申请公布号 |
WO9943787(A3) |
申请公布日期 |
1999.11.25 |
申请号 |
WO1999US03859 |
申请日期 |
1999.02.23 |
申请人 |
ADVANCED TISSUE SCIENCES, INC. |
发明人 |
NAUGHTON, GAIL, K.;PINNEY, R., EMMETT;MANSBRIDGE, JONATHAN, N. |
分类号 |
A61K35/12;A61K35/36;A61L27/00;A61L27/60;A61P17/02;A61P43/00;C12N5/071;C12N5/10 |
主分类号 |
A61K35/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|