| 摘要 |
<p>A compound of formula (I) or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein the compound of formula (I) is present in an amount that is effective as PARP inhibitors and wherein: Y represents the atoms necessary to form a fused 5- to 6-membered, aromatic or non-aromatic, carbocyclic or heterocyclic ring, wherein Y and any heteroatom(s) therein is unsubstituted or independently substituted with at least one non-interfering hydroxy, amino, nitro, dimethylamino, alkylamino, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl substituent; R?1 and R3¿ are independently hydrogen, alkyl, halo, alkenyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, double bonded oxygen, -COOR5, or a moiety selected from the group consisting of formulae (a), (b), (c), (d), (e), (f), (g) and wherein R7 is alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl; R2, when present, is hydrogen, alkyl, alkenyl, amino, cycloalkyl, cycloalkenyl, aralkyl or aryl; R?4, R5 and R6¿ are independently hydrogen, hydroxy, amino, dimethylamino, alkylamino, nitro, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl; wherein R?2, R4, R5 and R6¿ are unsubstituted or independently substituted with a moiety selected from the group consisting of alkyl, alkenyl, alkoxy, phenoxy, benzyloxy, cycloalkyl, cycloalkenyl, hydroxy, carboxy, carbonyl, amino, dimethylamino, alkylamino, amido, cyano, isocyano, nitro, nitroso, nitrilo, isonitrilo, imino, azo, diazo, sulfonyl, sulfoxy, thio, thiocarbonyl, alkylthio, sulfhydryl, halo, haloalkyl, trifluoromethyl and aryl.</p> |
