| 摘要 |
PROBLEM TO BE SOLVED: To impart both of excellent dynamic characteristics and rapid biodegradability by introducing biodegradable groups degraded in an implanted region into both terminals of a water-soluble straight chain high polymer piercing the cavity of a cyclic molecule to provide a molecular structure wherein the cyclic molecule is not dissociated so far as the terminal groups are not degraded. SOLUTION: Polyethylene glycol being a straight chain high polymer or a block copolymer of polyethylene glycol and polypropylene glycol pierces the cavity parts of a plurality of cyclic molecules (cyclodextrin). Oligopeptide chains, oligosaccharides or ester groups are introduced into both terminals of the block copolymer as molecular chains (biodegradable groups) degraded in an implanted region in a time-specifical manner. By this constitution, dynamic characteristics necessary for tissue reconstruction can be developed by an ultra- high-molecular structure consisting of cyclic molecules and the straight chain high polymer. After reconstruction, an implantation material can disappears rapidly from the implanted region by the dissociation of ultra-high molecules based on the hydrolysis of the terminal groups. |
