| 摘要 |
FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to peptides of the general formula (I): R<SB>1</SB>-CH<SB>2</SB>-CH<SB>2</SB>-CONH--CH(R<SB>2</SB>)CH<SB>2</SB>R<SB>3</SB> or their pharmaceutically acceptable salts where R<SB>1</SB> means hydrogen atom or hydrocarbon C<SB>1</SB>-C<SB>3</SB>-radical substituted with the functional group, for example, amino, amide with C<SB>1</SB>-C<SB>5</SB>-radical, C<SB>1</SB>-C<SB>7</SB>-urethane or carboxy-group or hydrocarbon C<SB>1</SB>-C<SB>3</SB>-radical substituted simultaneously with amino- or carboxy-group; carboxy-group can be esterified and amino-group can be substituted with acyl substituent or carbonic acid ester; R<SB>2</SB> means hydrogen atom or the functional group, for example, carboxyl that can be esterified; R<SB>3</SB> means indole or its methyl and/or hydroxyl derivatives being hydroxyl group can be acylated, alkylated or aralkylated, 5-6-membered saturated and unsaturated cyclic and heterocyclic substituents containing oxygen, sulfur and/or 1-3 nitrogen atoms or their methyl derivatives; if R<SB>1</SB> is NH<SB>2</SB>,NH<SB>2</SB>-CH<SB>2</SB>- and R<SB>2</SB> is H then R<SB>3</SB> does not mean -4-Im, -3-(5-OMe-Ind), -3-(5-OH-Ind); if R<SB>1</SB> means NH<SB>2</SB>,NH<SB>2</SB>-CH<SB>2</SB>- and R<SB>2</SB> means COOH then R<SB>3</SB> does not mean -4-Im and if R<SB>1</SB> means HOOC-CH(NH<SB>2</SB>)- and R<SB>2</SB> means H then R<SB>3</SB> does not mean -3-Ind, -3-(5-OH-Ind). Compounds (I) show properties of modulators of cytochrome P-420 system, metabolism of arachidonic acid, adrenal cortex hormones, macrophage activity and an antioxidant, antihypoxic, antiviral, lipid-regulating, antimetastatic, glucose-decreasing, adaptogenic and other kinds of therapeutic effect. Compounds of the formula (I) are synthesized by acylation of amino-group in the compound (II): NH<SB>2</SB>-CH-(R<SB>2</SB>)-CH<SB>2</SB>-R<SB>3</SB> with a carboxyl component: R<SB>1</SB>-CH<SB>2</SB>-CH<SB>2</SB>-COX where X is an activating group. EFFECT: improved me |
