A PROCESS FOR THE SYNTHESIS OF ALKOXYALKYL (TRIFLUOROMETHYLPHENYL) METHANONES
摘要
A new process is described for the preparation of (alkoxyalkyl) (4-trifluoromethylphenyl) methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl) (4-trifluoromethylphenyl) methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.
申请公布号
WO9958485(A1)
申请公布日期
1999.11.18
申请号
WO1999IN00010
申请日期
1999.03.30
申请人
SUN PHARMACEUTICALS INDUSTRIES LTD.;THENNATI, RAJAMANNAR;DEO, KESHAV;MIDHA, AJAY;CHANDRA, TILAK;PATEL, VIJAY