| 摘要 |
This invention provides compounds of structural Formula (I), wherein R<1> and R<2> are each, independently, hydrogen, nitrile, nitro, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, cycloalkylamino of 3-8 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, halogen, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, phenyl or phenyl mono-, di-, or tri-substituted with halogen, hydroxy, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or perfluoroalkoxy of 1-6 carbon atoms; R<3> and R<4> are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, aminoalkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms; R<5> is hydrogen, halogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, nitrile, alkoxy of 1-6 carbon atoms, aryloxy, arylalcoxy of 2-12 carbon atoms, arylsulfanyl; W is S, O, or NR<9>; R<9> is hydrogen or alkyl of 1-6 carbon atoms; X is O, -NR<6>-, or -(CH2)pNR<6>-; R<6> is hydrogen, or alkyl of 1-6 carbon atoms; p is 1 to 4; Y is methylene, carbonyl, -SO2-, or -SO-; Z is phenyl, heteroaryl, or naphthyl; R<7> and R<8> are each, independently, hydrogen, carboxyl, acyl of 2-7 carbon atoms, hydroxyl, hydroxyalkyl of 1-6 carbon atoms, hydroxyalkanoyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, aryl, aryloxy, aryloxycarbonyl, heteroaryloxycarbonyl, arylalkoxy of 6-12 carbon atoms, heteroaryl, alkanoyloxy of 1-6 carbon atoms, perfluoroalkanoyloxy of 1-6 carbon atoms, heteroaroyloxy, aroyloxy, tetrazolyl, mercapto, nitrile, amino, carbamoy, aminoalkyl of 1-6 carbon atoms, -NHSO2CF3, carboxyaldehyde, halogen, nitro, acylamino, or pyrimidyl optionally substituted with mercapto, 3-hydroxy-cyclobut-3-ene-4-yl-1,2-dione, or tetronic acid; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
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