| 摘要 |
<p>The present invention relates to a method of treating celiac disease comprising interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule. This may be provided by prohibiting or interfering with the deamidation of at least one glutamine residue by derivation of at least one glutamine residue in a gliadin or glutenine molecule in wheat flour by a chemical or enzymatic deamidation of gluten followed by chemical or enzymatic derivation of the generated carboxyl group(s). In a further aspect, the invention relates to a method of interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule and thereby treating celiac disease, the method comprising administering, to a patient having or suspected of having celiac disease, at least one of the following substances: (a) a substance which is capable of increasing the pH in the gastroduodenal tract of a subject, e.g. an antacidum, an anticholinergic agent, H2-receptor antagonists or a proton pump inhibitor, (b) a substance which is capable of eliminating deamidating bacteria in the gastroduodenal tract of a subject, e.g. an antibiotic or antimicrobial agent, and/or (c) a substance which is capable of interfering with the effect of at least one deamidating enzyme in the gastroduodenal tract of a subject.</p> |
