| 发明名称 |
USE OF MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS FOR ANTI-CANCER THERAPY |
| 摘要 |
<p>The present invention relates to methods of treating disorders related to cellular overproliferation comprising neutralizing the production or activity of macrophage migration inhibitory factor (MIF). The invention also relates to therapeutic compositions comprising factors which inhibit or neutralize MIF activity, such as, MIF antisense RNA molecules and MIF monoclonal antibodies and derivatives or analogs thereof. The invention further relates to the uses of such compositions and methods for the treatment of malignancies, including, but not limited to, B and T cell lymphomas.</p> |
| 申请公布号 |
EP0954334(A1) |
申请公布日期 |
1999.11.10 |
| 申请号 |
EP19970913963 |
申请日期 |
1997.10.24 |
| 申请人 |
THE PICOWER INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
BUCALA, RICHARD, J.;CHESNEY, JASON, A. |
| 分类号 |
C12N15/09;A01K67/027;A61K31/7076;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07K14/52;C07K14/575;C07K14/72;C07K16/00;C07K16/24;C07K16/26;C12N15/113;C12N15/85;C12P21/08;(IPC1-7):A61K39/395;A61K31/70;A01N43/04 |
主分类号 |
C12N15/09 |
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