METHOD OF SYNTHESIS OF LEUKOTRIENE ANTAGONISTS, DICYCLOHEXYL-AMINE SALT, METHODS OF PREPARING CRYSTALLINE SODIUM SALT AND 1-(MERCAPTOMETHYL)-CYCLOPROPANE ACETIC ACID, CRYSTALLINE COMPOUNDS

摘要

FIELD: organic chemistry. SUBSTANCE: invention describes a method of synthesis of the compound of the formula (I) <EMI ID=0.212 HE=36 WI=54 TI=CHI> where HET means 7-chloroquinoline-2-yl or 6,7-difluoro- -quinoline-2-yl. Method involves the generation of dilithium dianion of 1-(mercaptomethyl)-cyclopropane acetic acid by reaction of 1-(mercaptomethyl)-cyclopropane acetic acid with lithium base, interaction of indicated dianion with the compound of the formula (II) <EMI ID=0.213 HE=24 WI=54 TI=CHI> where HET means a value indicated above and L means arylsulfonyl or alkylsulfonyl followed by treatment with acid for generation of free acid of the compound of the formula (I) and optionally free acid is converted to the corresponding salt of dicyclohexylamine and then to sodium salt. EFFECT: development of the effective method providing the increased total yield of the end product, preparing the crystalline form. 14 cl, 6 dwg, 14 ex