DERIVATIVE OF 8-TRIFLUOROMETHYLQUINOLINE CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF IMMUNODEFICIENCY VIRUS

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a derivative of 8-trifluoro- -methylquinoline carboxylic acid of the formula (I) <EMI ID=0.223 HE=27 WI=57 TI=CHI> where R is lower alkyl, lower halogenalkyl or cycloalkyl; R is phenyl possibly substituted with R , 5- or 6-membered heteromonocycle containing 1 or 2 heteroatoms (N or S) possibly substituted with R , or 5-membered polyheteromonocyclic group containing 2 heteroatoms (N, O or S) condensed with benzene ring; R - halogen atom, alkyl, fluoro-substituted lower alkyl, lower alkoxyl, lower thioalkyl; R - H or lower alkyl; m = 2 or 3, or its pharmaceutically acceptable salt or ester. The composition inhibits the growth of human immunodeficiency virus. EFFECT: enhanced effectiveness of immunodeficiency virus inhibition. 24 cl, 12 tbl, 41 ex