发明名称 |
Solubilization of pharmaceutical substances in an organic solvent and preparation of pharmaceutical powders using the same |
摘要 |
Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host.
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申请公布号 |
US5981474(A) |
申请公布日期 |
1999.11.09 |
申请号 |
US19980098791 |
申请日期 |
1998.06.17 |
申请人 |
UNIVERSITY TECHNOLOGY CORPORATION |
发明人 |
MANNING, MARK C.;RANDOLPH, THEODORE W.;SHEFTER, ELI;FALK, III, RICHARD F. |
分类号 |
A61K9/00;A61K9/16;A61K9/51;A61K38/04;A61K38/22;A61K38/28;A61K38/57;A61K47/48;B01F3/00;C07K1/30;(IPC1-7):A61K38/00;A23J1/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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