摘要 |
Compounds represented by general formula (I) which show a tyrosine kinase inhibitory activity or salts thereof, wherein R<1> and R<2> represent each hydrogen, alkanoyl, etc.; Y represents optionally substituted alkylene; R<3> represents NR<5>R<6> (wherein R<5> represents hydrogen, optionally substituted lower alkyl, etc.; and R<6> represents substituted alkyl, etc.), NR<7>COR<8> [wherein R<7> represents hydrogen, optionally substituted alkyl, etc.; and R<8> represents substituted lower alkyl, substituted lower alkoxy, NR<9>R<10> (wherein R<9> and R<10> represent each hydrogen, optionally substituted lower alkyl, etc.)], NR<11>COR<12> (wherein R<11> represents optionally substituted lower alkyl, etc.; and R<12> represents lower alkyl, lower alkoxy, etc.), substituted lower alkoxy, optionally substituted alkenyloxy, etc.; X represents halogeno or forms together with R<4> a single bond; and R<4> forms together with X a single bond or represents hydrogen, alkanoyl, etc.
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申请人 |
KYOWA HAKKO KOGYO CO., LTD.;INO, YOJI;AMISHIRO, NOBUYOSHI;MIYATA, MAYUMI;AGATSUMA, TSUTOMU;MURAKATA, CHIKARA;AKINAGA, SHIRO;SOGA, SHIRO;SHIOTSU, YUKIMASA |
发明人 |
INO, YOJI;AMISHIRO, NOBUYOSHI;MIYATA, MAYUMI;AGATSUMA, TSUTOMU;MURAKATA, CHIKARA;AKINAGA, SHIRO;SOGA, SHIRO;SHIOTSU, YUKIMASA |