发明名称 |
Chloro or bromo[2-[2-(tert-butyl)-2H-tetrazol-5-yl]phenyl]zinc intermediates |
摘要 |
This application discloses a process for producing 8-[2'-(2(1)-tert-butyl-2H-tetrazol-5-yl) -biphenyl-4-yl-methyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (or such a compound wherein a benzyl or p-methoxybenzyl group is present in place of the tert-butyl group) or a salt thereof, said process characterized in (B) transmetallizing bromo[2-[2-(tert-butyl)-2H-tetrazol-5-yl]phenyl]magnesium Grignard reagent with zinc chloride or bromide; and (C) reacting the transmetallized product with 8-[(4-bromophenyl)-methyl]5,8-dihydro-2,4-dimethyl-pyrido[2,3-d]pyrimidin-7(6H-one in the presence of a palladium catalyst to yield the product; wherein throughout the process a benzyl or p-methoxybenzyl group may be present in place of the tert-butyl group.
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申请公布号 |
US5977372(A) |
申请公布日期 |
1999.11.02 |
申请号 |
US19980032129 |
申请日期 |
1998.02.27 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
GIGUERE, PIERRE;IERA, SILVIO;BERNATCHEZ, MICHEL |
分类号 |
B01J31/16;C07B61/00;C07D257/04;C07D471/04;C07F3/02;C07F3/06;C07F7/22;(IPC1-7):C07F3/06 |
主分类号 |
B01J31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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