| 发明名称 |
Oxidation process using tempo |
| 摘要 |
The present invention relates to an oxidation using sodium chlorite in the presence of a catalytic amount of TEMPO and sodium hypochlorite which converts the penultimate intermediate bearing a primary alcohol to the target endothelin antagonist compound of Formula (I) having a carboxylic acid. |
| 申请公布号 |
AU3471299(A) |
申请公布日期 |
1999.11.01 |
| 申请号 |
AU19990034712 |
申请日期 |
1999.04.05 |
| 申请人 |
MERCK & CO., INC.;BANYU PHARMACEUTICAL CO. LTD. |
发明人 |
PAUL N. DEVINE;ZHIGUO SONG;DAVID M TSCHAEN;MANGZU ZHAO;EIICHI MANO |
| 分类号 |
C07D221/04;C07D405/04 |
主分类号 |
C07D221/04 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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